This species is distinguished from other species of the C. missioneira group by having 6-8 slightly elongate blotches along middle portion of the body flank, below the upper lateral line scale row, no lateral band, numerous spots scattered over back, (sometimes forming a reticulated pattern) and sides in males, and an isognathous mouth. It is most similar to

C. igara and C. jurubi in color pattern, but both males and females of the latter species show the same scattered spots including those on the head and opercle vs. none in females and males of Crenicichla empheres which has the spots confined to the lateral of body. Other differences, C. jurubi may have the last three or four blotches contiguous without lighter space between them and/or mixing with the spotted pattern of the body) and

C. igara has prognathous mouth and no ocellated spot on the dorsal fin in females (Ref. 75870).